Ulwazi oluyisisekelo
| Igama Lomkhiqizo | Ikhathalogi | Uhlobo | Umsingathi/Umthombo | Ukusetshenziswa | Izinhlelo zokusebenza | I-Epitope | I-COA |
| I-HCV Core-NS3-NS5 fusion antigen | I-BMIHCV203 | I-Antigen | E.coli | Thwebula | I-CMIA,WB | / | Landa |
| I-HCV Core-NS3-NS5 fusion antigen | I-BMIHCV204 | I-Antigen | E.coli | Hlanganisa | I-CMIA,WB | / | Landa |
| I-HCV Core-NS3-NS5 fusion antigen-Bio | I-BMIHCVB02 | I-Antigen | E.coli | Hlanganisa | I-CMIA,WB | / | Landa |
| I-HCV Core-NS3-NS5 fusion antigen | I-BMIHCV213 | I-Antigen | HEK293 Iseli | Hlanganisa | I-CMIA,WB | / | Landa |
I-pathogenesis ye-hepatitis C ayikacaci.Lapho i-HCV iphindaphinda emangqamuzaneni esibindi, idala izinguquko esakhiweni nasekusebenzeni kwamangqamuzana esibindi noma iphazamise ukuhlanganiswa kwamaprotheni eseli yesibindi, okungabangela ukonakala kanye necrosis yamangqamuzana esibindi, okubonisa ukuthi i-HCV ilimaza isibindi ngokuqondile futhi idlala indima ku-pathogenesis.Kodwa-ke, izazi zezibalo eziningi zikholelwa ukuthi ukusabela kwe-cellular immunopathological kungase kudlale indima ebalulekile.Bathole ukuthi i-hepatitis C, njenge-hepatitis B, inamaseli angenayo e-CD3+ ezicutshini zayo.Amaseli e-Cytotoxic T (TC) ahlasela ngokuqondile amangqamuzana ahlosiwe okutheleleka kwe-HCV, angabangela ukulimala kwamangqamuzana esibindi.
I-RIA noma i-ELISA
I-Radioimmunodiagnosis (RIA) noma i-enzyme-linked immunosorbent assay (ELISA) yasetshenziselwa ukuthola i-anti HCV ku-serum.Ngo-1989, uKuo et al.isungule indlela ye-radioimmunoassay (RIA) ye-anti-C-100.Kamuva, i-Ortho Company yenza ngempumelelo i-enzyme-linked immunosorbent assay (ELISA) ukuze ithole i-anti-C-100.Zombili lezi zindlela zisebenzisa i-recombinant yeast express virus antigen (C-100-3, iphrotheni efakwe ikhodi yi-NS4, equkethe ama-amino acid angama-363), ngemva kokuhlanzwa, imbozwa ngenani elincane lezimbobo zamapuleti epulasitiki, bese yengezwa neserum ehloliwe.I-antigen yegciwane ibe isihlanganiswa ne-anti-C-100 ku-serum ehloliwe.Ekugcineni, i-isotope noma i-enzyme ebhalwe ukuthi igundane i-anti human lgG monoclonal antibody iyengezwa, futhi i-substrate yengezwa ukuze kunqunywe umbala.
